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O-GlcNAcylation in tumorigenesis and its implications for cancer therapy

Dize Zhang1, Yihang Qi2, Hiroyuki Inuzuka2

  • 1Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

The Journal of Biological Chemistry
|August 23, 2024
PubMed

Insights

O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a key protein modification in cancer. This review explores its role in tumorigenesis and potential as a therapeutic target for anticancer drugs.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic posttranslational modification of serine/threonine residues.
  • Uridine diphospho-N-acetylglucosamine, derived from glucose, is the GlcNAc donor.
  • O-GlcNAc transferase and O-GlcNAcase regulate O-GlcNAcylation.
  • This modification is implicated in various cellular processes, including cancer.

Purpose of the Study:

  • To review the tumor-related biological functions of O-GlcNAcylation.
  • To summarize recent advancements in pharmaceutical strategies targeting O-GlcNAcylation for cancer therapy.

Main Methods:

  • Literature review of O-GlcNAcylation in cancer.
  • Analysis of enzymatic pathways and protein substrates involved.
  • Survey of emerging pharmaceutical agents and their mechanisms.

Main Results:

  • O-GlcNAcylation significantly influences tumorigenesis and cancer progression.
  • Specific protein substrates are modulated by O-GlcNAcylation, impacting cancer pathways.
  • Emerging drugs aim to modulate O-GlcNAcylation for therapeutic benefit.

Conclusions:

  • O-GlcNAcylation is a critical factor in cancer biology.
  • Targeting O-GlcNAcylation presents a promising avenue for novel anticancer therapies.
  • Further research into O-GlcNAcylation modulators is warranted.
Keywords:
O-GlcNAcylationcancer therapychemical-induced proximitytumorigenesis

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