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Updated: Jun 15, 2025
Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
Published on: January 10, 2025
Hydrogen sulfide plays an important role by regulating microRNA in different ischemia-reperfusion injury
Qi Zhang1, Yanting Zhang1, Shiyun Guo1
1Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Abstract:
MicroRNAs (miRNAs) are the short endogenous non-coding RNAs that regulate the expression of the target gene at posttranscriptional level through degrading or inhibiting the specific target messenger RNAs (mRNAs). MiRNAs regulate the expression of approximately one-third of protein coding genes, and in most cases inhibit gene expression. MiRNAs have been reported to regulate various biological processes, such as cell proliferation, apoptosis and differentiation. Therefore, miRNAs participate in multiple diseases, including ischemia-reperfusion (I/R) injury. Hydrogen sulfide (H2S) was once considered as a colorless, toxic and harmful gas with foul smelling. However, in recent years, it has been discovered that it is the third gas signaling molecule after carbon monoxide (CO) and nitric oxide (NO), with multiple important biological functions. Increasing evidence indicates that H2S plays a vital role in I/R injury through regulating miRNA, however, the mechanism has not been fully understood. In this review, we summarized the current knowledge about the role of H2S in I/R injury by regulating miRNAs, and analyzed its mechanism in detail.
Insights
Hydrogen sulfide (H2S) regulates microRNAs (miRNAs) to impact ischemia-reperfusion (I/R) injury. This review details the mechanisms by which H2S influences miRNAs in I/R injury.
Area of Science:
- Molecular Biology
- Biochemistry
- Physiology
Background:
- MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression, influencing numerous biological processes.
- MiRNAs are implicated in the pathogenesis of various diseases, including ischemia-reperfusion (I/R) injury.
- Hydrogen sulfide (H2S), a newly recognized gasotransmitter, possesses significant biological functions.
Purpose of the Study:
- To review and summarize the current understanding of hydrogen sulfide's role in I/R injury.
- To elucidate the mechanisms through which H2S modulates miRNA expression and function in I/R injury.
Main Methods:
- Literature review of existing studies on H2S, miRNAs, and I/R injury.
- Analysis of experimental data and mechanistic insights from published research.
Main Results:
- Evidence suggests H2S plays a critical role in mitigating I/R injury.
- H2S exerts its protective effects, in part, by regulating specific miRNAs.
- The precise molecular mechanisms linking H2S and miRNA regulation in I/R injury are complex and multifaceted.
Conclusions:
- Hydrogen sulfide is a significant endogenous regulator involved in the pathophysiology of I/R injury.
- Understanding the H2S-miRNA axis offers potential therapeutic strategies for I/R injury.
- Further research is needed to fully unravel the intricate mechanisms governing H2S-mediated miRNA regulation in I/R.
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