Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

34
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
34
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

45
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
45
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

241
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
241
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

468
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
468
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

188
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
188
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

104
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
104

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating Intragastric Disintegration Times of Immediate Release Dose Units Administered After a High-Calorie, High-Fat Meal Using Standardized, Commercially Available Equipment and Materials.

The AAPS journal·2026
Same author

PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.

The AAPS journal·2026
Same author

Impact of chronological ageing on tight junction-related gene expression at the human gastrointestinal epithelium: An exploratory study.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Chronological age, proton pump inhibitors in older adults, and diabetes in older adults on physicochemical characteristics of contents of the descending duodenum during fasting: An exploratory study.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Screening adsorbents for the prevention of drug-induced intestinal dysbiosis at pre-formulation stage: case example activated charcoal.

The Journal of pharmacy and pharmacology·2025
Same author

PROTAC Enabling Formulation <i>In Vivo</i>: Implications of the Polymeric Carrier Eudragit E PO.

Molecular pharmaceutics·2025

Related Experiment Video

Updated: Jun 15, 2025

Author Spotlight: Exploring Light-Driven Chemical Reactions and Energy-Harnessing Devices in Photochemical Research
08:12

Author Spotlight: Exploring Light-Driven Chemical Reactions and Energy-Harnessing Devices in Photochemical Research

Published on: February 16, 2024

8.8K

Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach.

Donnia Robins1, Andreas Lehmann2, Katharina Krollik2

  • 1Global Drug Product Development, Global CMC Development, Merck KGaA, Frankfurter Straße 250, Darmstadt, Germany; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|August 23, 2024
PubMed
Summary

Physiologically based pharmacokinetic (PBPK) models were enhanced with global sensitivity analysis to assess age-related absorption changes. This approach improves risk analysis for drug safety in older populations.

Keywords:
Global sensitivity analysisMorrisOlder peoplePK-Sim®Physiologically based pharmacokinetic modellingRisk Screening

More Related Videos

Characterization of Biological Absorption Spectra Spanning the Visible to the Short-Wave Infrared
07:38

Characterization of Biological Absorption Spectra Spanning the Visible to the Short-Wave Infrared

Published on: January 10, 2025

1.1K
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
06:21

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

8.1K

Related Experiment Videos

Last Updated: Jun 15, 2025

Author Spotlight: Exploring Light-Driven Chemical Reactions and Energy-Harnessing Devices in Photochemical Research
08:12

Author Spotlight: Exploring Light-Driven Chemical Reactions and Energy-Harnessing Devices in Photochemical Research

Published on: February 16, 2024

8.8K
Characterization of Biological Absorption Spectra Spanning the Visible to the Short-Wave Infrared
07:38

Characterization of Biological Absorption Spectra Spanning the Visible to the Short-Wave Infrared

Published on: January 10, 2025

1.1K
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
06:21

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

8.1K

Area of Science:

  • Pharmacokinetics and Drug Development
  • Geriatric Pharmacology
  • Computational Modeling

Background:

  • Older adults face higher risks of adverse drug effects due to altered pharmacokinetics, particularly absorption.
  • Limited data and high variability complicate understanding drug absorption changes in the elderly.
  • Physiologically based pharmacokinetic (PBPK) models offer advantages for studying special populations like the elderly.

Purpose of the Study:

  • To integrate global sensitivity analysis with PBPK models to characterize age-associated absorption changes.
  • To evaluate the impact of age-related absorption variability on drug pharmacokinetics.
  • To improve risk assessment for oral drug dosing in advanced age populations.

Main Methods:

  • Physiologically based pharmacokinetic (PBPK) models were developed using PK-Sim®.
  • Global sensitivity analysis, specifically the Elementary Effects (Morris) method, was implemented in R.
  • Three drugs from Biopharmaceutical Classification System classes I-III were tested against three age-associated hypotheses.

Main Results:

  • Successfully integrated global sensitivity analysis with PBPK models for age-related absorption.
  • Demonstrated the utility of the Morris method for assessing parametric interactions in PBPK models.
  • Quantified the impact of age-associated absorption changes on drug pharmacokinetics for selected drugs.

Conclusions:

  • Global sensitivity analysis provides a robust method for PBPK model risk assessment in special populations.
  • This integrated approach enhances the characterization of age-related pharmacokinetic variability.
  • Improved PBPK modeling can better predict and mitigate drug-related risks in older adults.