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NO- and H2S- releasing nanomaterials: A crosstalk signaling pathway in cancer

Roberta Albino Dos Reis1, Ishani Sarkar2, Maiara Gonçalves Rodrigues1

  • 1Center for Natural and Human Sciences, Federal University of ABC, Santo André, 09210-580, SP, Brazil.

Nitric Oxide : Biology and Chemistry
|August 23, 2024
PubMed

Insights

Nitric oxide (NO) and hydrogen sulfide (H2S) gasotransmitters have dual roles in cancer. Nanomaterials offer targeted delivery for synergistic anticancer therapies, potentially reversing drug resistance and minimizing side effects.

Area of Science:

  • Biochemistry and Molecular Biology
  • Nanomedicine
  • Oncology

Background:

  • Gasotransmitters nitric oxide (NO) and hydrogen sulfide (H2S) are critical in physiological and pathological processes.
  • These molecules exhibit complex, context-dependent roles in cancer, with both tumor-promoting and anti-tumor activities.
  • Cellular responses to NO and H2S vary significantly across different cell types.

Purpose of the Study:

  • To review recent advancements in NO- and H2S-releasing nanomaterials for cancer therapy.
  • To explore the synergistic potential of gasotransmitters with conventional anticancer treatments.
  • To highlight the role of nanomaterials in targeted delivery and overcoming multidrug resistance.

Main Methods:

  • Literature review focusing on the design and application of NO- and H2S-releasing nanomaterials.
  • Analysis of the interplay between NO and H2S in various cancer contexts.
  • Examination of nanomaterial-based strategies for enhanced drug delivery and reduced toxicity.

Main Results:

  • Nanomaterials provide a promising platform for the targeted delivery of NO and H2S donors.
  • Gasotransmitters can synergize with radiotherapy, immunotherapy, chemotherapy, and phototherapy.
  • NO and H2S have demonstrated potential in reversing multidrug resistance in cancer cells.

Conclusions:

  • NO- and H2S-releasing nanomaterials represent a significant advancement in targeted cancer therapy.
  • Understanding the complex interactions between NO and H2S is crucial for developing effective combination therapies.
  • Nanomedicine approaches offer enhanced therapeutic efficiency and reduced side effects in cancer treatment.
Keywords:
Cancer cellsDrug deliveryHydrogen sulfideNanomaterialsNitric oxideToxicity

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