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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Correlation between choroidal parameters and primary angle-closure suspect in different age groups.

Mengyang Li1, Zhi Li1, Fei Xiang1

  • 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.

BMJ Open Ophthalmology
|August 23, 2024
PubMed
Summary
This summary is machine-generated.

Primary angle-closure suspect (PACS) eyes in individuals aged 50-60 showed increased choroidal thickness and volume. Greater choroidal volume is a predisposing factor for PACS in this age group.

Keywords:
ChoroidGlaucoma

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Area of Science:

  • Ophthalmology
  • Anatomy
  • Biometry

Background:

  • Primary angle-closure suspect (PACS) is a risk factor for primary angle-closure glaucoma.
  • Choroidal changes may play a role in the pathophysiology of PACS.
  • Understanding age-related differences in choroidal parameters is crucial for risk stratification.

Purpose of the Study:

  • To investigate the correlations between choroidal parameters and primary angle-closure suspect (PACS).
  • To analyze these correlations in different age subgroups.
  • To identify potential predisposing factors for PACS based on choroidal characteristics.

Main Methods:

  • Participants aged 50 years or older from Beijing were recruited.
  • Swept-source optical coherence tomography (OCT) was used to measure choroidal parameters.
  • Logistic analysis explored the association between choroidal parameters and PACS, with subgroup analysis by age.

Main Results:

  • In the 50-60 year group, PACS eyes had significantly greater subfoveal choroidal thickness and volume compared to non-PACS (NPACS) eyes.
  • No significant differences in choroidal parameters were found between PACS and NPACS eyes in the >60 year group.
  • Multivariate regression confirmed increased choroidal volume as a significant predictor (OR 1.298, p<0.001) of PACS in the 50-60 year group.

Conclusions:

  • In individuals aged 50-60 years, PACS eyes exhibit increased choroidal thickness and volume.
  • Increased total choroidal volume is identified as a predisposing factor for PACS in this specific age demographic.
  • These findings highlight the importance of choroidal assessment in younger individuals at risk for angle closure.