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Updated: Jun 15, 2025
Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
Evaluation of small fibre neuropathies
Naveed Malek1, Joseph Hutchinson2, Asma Naz2
1Department of Neurophysiology, National Hospital for Neurology and Neurosurgery, London, UK nmalek@nhs.net.
Small fibre neuropathies (SFNs) cause pain and autonomic issues. This review details neurophysiological tests for diagnosing SFNs, highlighting current limitations and future diagnostic advancements.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Small fibre neuropathies (SFNs) are prevalent neurological disorders.
- SFNs significantly impact patient quality of life through pain and autonomic dysfunction.
Purpose of the Study:
- To review neurophysiological tests for diagnosing SFNs.
- To discuss the sensitivity, specificity, and limitations of these diagnostic methods.
Main Methods:
- Focus on neurophysiological investigations.
- Analysis of existing diagnostic techniques for SFNs.
Main Results:
- Current neurophysiological tests aid in SFN diagnosis.
- Some diagnostic tests are restricted to specialist centers.
- Emerging technologies promise improved future diagnostics.
Conclusions:
- Neurophysiological testing is crucial for SFN diagnosis.
- Limitations exist in current diagnostic accessibility and technology.
- Advancements in neurophysiology are expected to enhance SFN diagnosis.
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