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Updated: Jun 15, 2025

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
Published on: September 23, 2021
Direct Chiral Discrimination with NMR
Sagar Wadhwa1,2, Dominique Buyens2, Jan G Korvink2
1Voxalytic GmbH, Rosengarten 3, 76228, Karlsruhe, Germany.
Abstract:
Unaided nuclear magnetic resonance (NMR) spectroscopy is considered incapable of distinguishing enantiomers. However, as first derived by A.D. Buckingham, the tensor coupling the electric and magnetic dipoles is space-dependent, which varies according to the molecular structure, hence, would be different for two enantiomers. Exploiting the odd-parity coupling tensor, a new variant of a double-resonant radiofrequency (RF) NMR detector is developed, which is sensitive to both electric and magnetic dipoles. Using the detector, a new method for liquid-state NMR is developed and elaborated, with which two enantiomers are successfully discriminated.
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