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High-dose Vitamin-B6 reduces sensory over-responsivity.

Rebekah O Cracknell1, Teresa Tavassoli1, David T Field1

  • 1School of Psychology and Clinical Language Sciences, The University of Reading, Reading, Berkshire, UK.

Journal of Psychopharmacology (Oxford, England)
|August 24, 2024
PubMed
Summary
This summary is machine-generated.

High-dose Vitamin-B6 supplementation effectively reduced sensory over-responsivity (SOR) and postural disorder in adults. This suggests Vitamin-B6 may be a viable intervention for individuals experiencing sensory processing challenges.

Keywords:
GABAautismexcitation–inhibition balanceglutamatesensory hyperreactivity

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Nutritional Science

Background:

  • Sensory reactivity differences affect 5-15% of the population, often manifesting as sensory over-responsivity (SOR).
  • SOR involves experiencing sensory stimuli intensely, impacting daily functioning.
  • A potential cause of SOR is an imbalance between neural excitation and inhibition, with weakened inhibitory influences.

Purpose of the Study:

  • To determine if high-dose Vitamin-B6 supplementation can reduce sensory over-responsivity (SOR) and other sensory reactivity aspects.
  • To investigate the efficacy of Vitamin-B6 in modulating neural pathways involved in sensory processing.

Main Methods:

  • 300 adults completed the Sensory Processing 3-Dimensions Scale (SP-3D) at baseline and after 1 month of supplementation.
  • Participants were randomized to receive 100 mg Vitamin-B6, 1000 µg Vitamin-B12, or placebo.
  • Analysis focused on individuals with high baseline SOR scores (above the 87th percentile).

Main Results:

  • Vitamin-B6 selectively reduced SOR compared to placebo and Vitamin-B12 in individuals with baseline SOR.
  • Vitamin-B6 also selectively reduced postural disorder in those with high baseline scores for this subscale.
  • No significant effects were observed on the remaining four SP-3D subscales.

Conclusions:

  • High-dose Vitamin-B6 shows promise in reducing sensory over-responsivity and postural disorder.
  • Further clinical trials and mechanistic studies are warranted in populations with SOR, such as autism and ADHD.
  • Vitamin-B6's role as a coenzyme in GABA synthesis suggests a potential neurobiological mechanism for its effects.