Mediating effects of carbon monoxide on the development of hypertension in China

Understanding the relationship between ambient carbon monoxide (CO) exposure and hypertension is crucial for advancing public health research. We investigated the association between air pollution CO exposure and hypertension and determined whether various health indicators played a mediating role.

Cross-sectional population-based study.

Our study examined the data of 13,240 participants in the China Health and Aging Longitudinal Study (CHARLS) conducted in 2015. A logistic regression approach was used to investigate the association between CO concentration and hypertension. The mediating effects (MEs) of health indicators on the association between carbon monoxide and hypertension prevalence were explored using mediation models.

Hypertension was diagnosed in 2953 of the participants. A significantly increased prevalence of hypertension was associated with higher concentrations of air pollutant CO after adjusting for all covariates (OR: 1.19, 95% CI: 1.04-1.37) in the matched group (OR: 1.21, 95% CI: 1.03-1.42). The study also showed that proportional mediation was 3.7% by TG, -5.3% by TC, -2.9% by LDL-C and 19.0% by HDL-C for blood lipid; 4.6% by FPG and 12.2% by HbA1c for blood glucose; -2.0% by grip strength and 16.2% by chair rising time for muscle strength; 59.6% by WC and 1.8% by BMI for obesity indicator and -2.3% by nighttime sleep and 7.8% by daytime nap for sleep duration.

A significant positive association has been found between environmental CO exposure and hypertension, and obesity, muscle strength, sleep duration, and metabolic factors may play a significant role in mediating this association.