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Updated: Jun 15, 2025
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
A Systematic Review of Single-Layer Versus Double-Layer Intestinal Anastomosis: Is One Better?
David E M Winston1, Nancy Pina1, Tomasz Kasprzycki1
1Department of General Surgery, TidalHealth, Salisbury, Maryland.
Introduction:
To perform a systematic review of randomized controlled trials comparing outcomes from handsewn single-layer and double-layer intestinal anastomosis in adults.
Methods:
A literature search was conducted using PubMed, SCOPUS, and Web of Science databases for studies published up to September 14, 2023 using the following keyword search query: ((one) OR (single)) AND ((two) OR (double)) AND (layer) AND ((anastomoses) OR (anastomosis)).
Results:
In seven of the eight studies, there was no significant difference in anastomotic leakage rate. In one of the eight studies, Moeen et al., double-layer anastomosis was associated with a significantly higher anastomotic leakage rate than single-layer anastomosis (5/100 versus 15/100, P = 0.018). Time to complete single-layer anastomosis was shorter than double-layer anastomosis.
Conclusions:
Single-layer and double-layer intestinal anastomosis have similar rates of anastomotic leak, mortality, and hospital stay in adults, with single-layer intestinal anastomosis having the benefit of shorter time to complete.
