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Related Experiment Video

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PhagoScreener: A novel phagogram platform based on a capillary-wave microbioreactor.

Kevin Viebrock1, Jana Wilhelm1, Bea Rölke1

  • 1Institute of Biochemical Engineering, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany; Center of Pharmaceutical Engineering, Technische Universität Braunschweig, Franz-Liszt-Str. 35a, 38106 Braunschweig, Germany.

New Biotechnology
|August 24, 2024
PubMed
Summary
This summary is machine-generated.

Phage therapy offers a promising alternative to antibiotics for combating drug-resistant bacteria. A novel capillary-wave microbioreactor (cwMBR) enables efficient, automated phagograms for personalized phage selection, improving treatment strategies.

Keywords:
E. coli phagesMicrobioreactorsPersonalized medicinePhage screeningPhagograms

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Area of Science:

  • Microbiology
  • Biotechnology
  • Bioengineering

Background:

  • Antibiotic resistance is a growing global health threat.
  • Phage therapy, using bacteriophages, is a potential alternative treatment.
  • Current methods for selecting therapeutic phages (phagograms) are labor-intensive and lack automation.

Purpose of the Study:

  • To demonstrate the applicability of a novel capillary-wave microbioreactor (cwMBR) for performing phagograms.
  • To assess the potential of cwMBR for automated and parallelized phage selection.
  • To evaluate cwMBR's online biomass measurement capability for phagogram analysis.

Main Methods:

  • Phagograms were performed using E. coli and two bacteriophages (MM02, EASG3) in a 7 µL cwMBR.
  • Bacterial lysis kinetics and phage efficacy were monitored via online biomass measurement.
  • Results were compared to conventional microtiter plate reader assays.

Main Results:

  • The cwMBR successfully performed phagograms, detecting differences in lysis kinetics between phages.
  • The open-droplet design and small volume facilitated automation and parallelization potential.
  • cwMBR demonstrated favorable mixing and a phage-repellent surface for efficient assays.

Conclusions:

  • The capillary-wave microbioreactor (cwMBR) is a suitable platform for performing phagograms.
  • cwMBR offers advantages in automation, parallelization, and online monitoring for phage selection.
  • This technology presents an ideal alternative to conventional methods for high-throughput phagogram analysis.