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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Approach to Mycosis Fungoides in children: Consensus-based recommendations.

Alex Zvulunov1, Holly Neale2, Jonah Stern3

  • 1Sheba Medical Center, Tel-Hashomer and Reichman University, Herzlia, Israel; Pediatric Dermatology Research Alliance, Portland, Oregon.

Journal of the American Academy of Dermatology
|August 24, 2024
PubMed
Summary

Pediatric Mycosis fungoides (MF) management now has new consensus recommendations. These guidelines incorporate clinical severity, quality of life, and psychological factors for early and advanced pediatric MF cases.

Keywords:
consensusmycosis fungoidespediatricseverity and outcome measures

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Area of Science:

  • Dermatology
  • Pediatric Oncology

Background:

  • Current pediatric Mycosis fungoides (MF) management relies on adult guidelines, overlooking distinct clinical presentations in children.
  • Development of specific recommendations is crucial for effective pediatric MF care.

Purpose of the Study:

  • To establish consensus-based management recommendations tailored for pediatric Mycosis fungoides (MF).

Main Methods:

  • An international panel of 83 experts in pediatric dermatology, dermatology, dermatopathology, and pediatric hematology-oncology participated.
  • A three-round electronic Delphi process followed by a modified Nominal Group Technique meeting refined the recommendations.

Main Results:

  • Consensus recommendations were established for managing early and advanced pediatric MF.
  • Severity assessment now includes pruritus, functional/esthetic impact, quality of life, and psychological distress, alongside parental anxiety, exceeding traditional staging.
  • Therapeutic choices for stages beyond MF Stage I showed some disagreement among experts.

Conclusions:

  • A multinational effort successfully generated consensus recommendations to standardize pediatric MF management.
  • Further research is required for structured, prospective protocols, particularly for advanced-stage pediatric MF.
  • Systematic, prospective data collection is essential for advancing pediatric MF treatment.