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Precision medicine for Defence?
Stuart Jon Armstrong1, K King2, G Steventon3
1Defence Science and Technology Laboratory, Salisbury, UK sjarmstrong@dstl.gov.uk.
Pharmacogenomics studies how genes affect drug response. Understanding genetic variants in drug-metabolizing enzymes like cytochrome P450s can predict individual patient responses to medications, improving treatment efficacy and safety.
Area of Science:
- Pharmacogenomics and Precision Medicine
- Genetics and Drug Metabolism
Background:
- Individual drug response is influenced by genetic variations in proteins like enzymes and receptors.
- Pharmacogenomics, the study of genes influencing drug response, has advanced understanding of drug-metabolizing enzymes, particularly cytochrome P450s.
- Genetic variants in cytochrome P450 enzymes are common in the UK population, leading to diverse metabolic phenotypes (ultra-rapid, extensive, intermediate, poor).
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