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Updated: Jun 15, 2025
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Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
Published on: July 6, 2022
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Goblet cell adenocarcinoma
Jula Veerapong1, Mojgan Hosseini1
1University of California San Diego, USA.
Seminars in Diagnostic Pathology
|August 24, 2024
Summary
Goblet cell adenocarcinoma (GCA) is a rare appendiceal tumor. This review clarifies its pathology, nomenclature, and the 2019 World Health Organization classification system for better understanding of this amphicrine neoplasm.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- The appendix is an underrecognized source of abdominal tumors.
- Goblet cell adenocarcinoma (GCA) is a rare appendiceal neoplasm.
- Previous nomenclature and classifications have caused confusion.
Purpose of the Study:
- To provide an updated review of goblet cell adenocarcinoma.
- To clarify the nomenclature and classification of GCA.
- To emphasize the 2019 World Health Organization (WHO) classification and grading system.
Main Methods:
- Literature review focusing on appendiceal tumors.
- Analysis of recent pathological and classification updates.
- Emphasis on the 2019 WHO Classification of Tumors.
Main Results:
- GCA has a complex history of nomenclature changes.
- The 2019 WHO classification provides a standardized approach.
- A 3-tiered grading system is highlighted for GCA.
Conclusions:
- Standardized nomenclature and classification are crucial for GCA.
- The 2019 WHO system aids in consistent diagnosis and grading.
- Further research into this amphicrine tumor is warranted.
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