Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

78
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
78
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

5.4K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.4K
Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of an integrated process including sand media, constructed wetland, and nylon 6 membrane in wastewater treatment of the herbal essences industry.

Environmental science and pollution research international·2026
Same author

Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Concurrent presentation of appendiceal sessile serrated lesions with other appendiceal neoplasms.

Human pathology·2026
Same author

Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Time-Restricted Feeding Is Not Effective in Modulating Fibrosis in a Male MASH Model.

Journal of biological rhythms·2025
Same author

Promotion of skin regeneration in diabetic rats by collagen-based hydrogel incorporated with basic fibroblast growth factor: A histological, molecular, and tensiometrical study.

Tissue & cell·2025

Related Experiment Video

Updated: Jun 15, 2025

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

3.8K

Goblet cell adenocarcinoma.

Jula Veerapong1, Mojgan Hosseini1

  • 1University of California San Diego, USA.

Seminars in Diagnostic Pathology
|August 24, 2024
PubMed
Summary
This summary is machine-generated.

Goblet cell adenocarcinoma (GCA) is a rare appendiceal tumor. This review clarifies its pathology, nomenclature, and the 2019 World Health Organization classification system for better understanding of this amphicrine neoplasm.

Keywords:
AdenocarcinoidAdenocarcinoma ex goblet cell carcinoidAdenoneuroendocrineGoblet cell adenocarcinoma, goblet cell carcinoidMixed adenoneuroendocrine carcinoma

More Related Videos

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.5K
Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
08:31

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

9.9K

Related Experiment Videos

Last Updated: Jun 15, 2025

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

3.8K
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.5K
Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
08:31

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

9.9K

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • The appendix is an underrecognized source of abdominal tumors.
  • Goblet cell adenocarcinoma (GCA) is a rare appendiceal neoplasm.
  • Previous nomenclature and classifications have caused confusion.

Purpose of the Study:

  • To provide an updated review of goblet cell adenocarcinoma.
  • To clarify the nomenclature and classification of GCA.
  • To emphasize the 2019 World Health Organization (WHO) classification and grading system.

Main Methods:

  • Literature review focusing on appendiceal tumors.
  • Analysis of recent pathological and classification updates.
  • Emphasis on the 2019 WHO Classification of Tumors.

Main Results:

  • GCA has a complex history of nomenclature changes.
  • The 2019 WHO classification provides a standardized approach.
  • A 3-tiered grading system is highlighted for GCA.

Conclusions:

  • Standardized nomenclature and classification are crucial for GCA.
  • The 2019 WHO system aids in consistent diagnosis and grading.
  • Further research into this amphicrine tumor is warranted.