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Related Experiment Videos

Mitomycin C extravasation ulcers.

A K Khanna, A Khanna, A K Asthana

    Journal of Surgical Oncology
    |February 1, 1985
    PubMed
    Summary

    Mitomycin C extravasation causes painful, non-healing ulcers. Prompt recognition and intervention, including surgical excision and closure or grafting, are crucial for managing these difficult mitomycin C side effects.

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    Area of Science:

    • Oncology
    • Dermatology
    • Surgical Oncology

    Background:

    • Mitomycin C is a chemotherapy agent used in various cancers.
    • Extravasation of mitomycin C can lead to severe tissue damage.
    • Indolent, non-healing ulcers are a known complication of mitomycin C extravasation.

    Purpose of the Study:

    • To report on the incidence and management of mitomycin C extravasation ulcers.
    • To highlight the clinical characteristics and treatment outcomes.
    • To provide recommendations for the management of these ulcers.

    Main Methods:

    • Retrospective review of eight patients over a four-year period.
    • Documentation of mitomycin C extravasation events and subsequent ulcer development.
    • Surgical management including excision and closure or skin grafting.

    Main Results:

    • Eight cases of mitomycin C extravasation ulcers were identified.
    • Ulcers were characterized as painful and indolent with poor healing tendency.
    • Successful management involved surgical excision with primary closure or partial thickness skin grafting.

    Conclusions:

    • Mitomycin C extravasation necessitates immediate cessation of infusion and site change.
    • Surgical intervention, including excision and closure/grafting, is the recommended treatment for these ulcers.
    • Prompt recognition and appropriate management are key to addressing mitomycin C-induced tissue injury.

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