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Updated: Jun 15, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

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Kaposi sarcoma and vertebral involvement in people with HIV: a case report and systematic literature review

Maria Mazzitelli1, Davide Leoni1, Alberto Maraolo2

  • 1Infectious and Tropical Diseases Unit, Padua University Hospital, Padova, Italy.

HIV Research & Clinical Practice
|August 25, 2024
PubMed

Insights

Kaposi Sarcoma (KS) spine involvement in people with HIV is rare but serious. Late diagnosis and visceral spread indicate a poor prognosis, highlighting the need for increased HIV testing and access to care.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Kaposi Sarcoma (KS) is historically linked to advanced HIV infection and immunosuppression.
  • While KS prevalence has decreased, late diagnosis and visceral involvement present management challenges.
  • Vertebral bone localization of KS is a rare but significant clinical presentation.

Approach:

  • A systematic literature review following PRISMA guidelines was conducted.
  • The review included all reported cases of vertebral KS in people with HIV from 1981 to 2023.
  • Data analysis focused on demographic, clinical characteristics, and treatment outcomes.

Key Points:

  • Twenty-two cases of vertebral KS in people with HIV were identified, predominantly affecting males with low CD4+ T cell counts and high viral loads.
  • Thoracic and lumbar spine involvement was most common, with pathological fractures occurring in two cases.
  • Treatment included chemotherapy (50%) and radiotherapy (18.2%), with varied outcomes including mortality (22.7%) and disease progression (9.9%).

Conclusions:

  • Late presentation of KS, particularly with spinal involvement, is associated with a poor prognosis despite treatment advancements.
  • Increased efforts are crucial for promoting HIV testing, especially in individuals presenting with indicative symptoms.
  • Early detection and management are vital for improving outcomes in patients with Kaposi Sarcoma.
Abstract

Keywords:
HIVKSKaposi sarcomaadvanced HIV diseasesreviewvertebral localization

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