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Updated: Jun 15, 2025
Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
Published on: December 6, 2024
Comparison of clinical parameters of peri-implantitis and parameters related to tissue macrophage sensitization on
Philipp Sahrmann1, Jens Tartsch2, Patrick R Schmidlin3
1Department of Periodontology, Endodontology and Cariology, University Centre for Dental Medicine, University of Basel, Basel, Switzerland. Philipp.sahrmann@unibas.ch.
Objective:
Dental implants show impressive survival and like rates, but peri-implantitis is a frequent inflammatory disease which affects the implant-surrounding tissues. While biofilms on the implant surface is considered its etiologic reason, several risk factors determine the pace of progression of peri-implant bone loss. Some risk factors are generally accepted while others are still unconfirmed and a matter of ongoing discussion. Among the latter, tissue macrophage sensitization on TiO2 has gained scientific interest in recent years. The aim of the present case-control study was to test for potential associations between clinically manifest peri-implantitis and MS related parameters.
Materials And Methods:
In patients with implants affected by peri-implantitis in the test group and healthy implants in the control group clinical parameters (peri-implant pocket depths (PPD) and bleeding on probing (BOP) were measured. Samples of aMMP-8 were taken from the entrance of the peri-implant sulcus and bacterial samples were collected from the sulcus. Blood samples were obtained from the basilic vein to assess MA-related laboratory parameters. Potential correlations between clinical and laboratory parameters were tested by multiple regression (p < 0.05).
Results:
No statistically significant correlations were found between clinical or bacteriological findings and laboratory parameters were found.
Conclusions:
Based on the findings of this study elevated MA-related laboratory parameters do not appear to be linked to peri-implantitis.
Clinical Relevance:
Sensitization on TiO2 is not associated with clinical symptoms of peri-implantitis.
