β-Cyclodextrin mediated controlled release of phenothiazine from pH-responsive pectin and pullulan-based hydrogel
1Polymer and Nanomaterial Lab, Department of Chemistry, Dr B R Ambedkar National Institute of Technology, Jalandhar 144008, Punjab, India.
International Journal of Biological Macromolecules
|August 25, 2024
Summary
This study developed phenothiazine and beta-cyclodextrin inclusion complexes (ICs) using various methods. Freeze-drying and microwave methods proved most effective for sustained drug release, offering improved formulation strategies.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Poorly soluble drugs like phenothiazine present formulation challenges.
- Beta-cyclodextrin is explored to enhance drug properties.
- Developing safe and efficient drug formulations is crucial.
Purpose of the Study:
- To prepare and characterize phenothiazine-beta-cyclodextrin inclusion complexes (ICs).
- To evaluate different preparation methods for optimal ICs.
- To investigate sustained drug release from optimized formulations.
Main Methods:
- Inclusion complexes prepared via physical, microwave, freeze-drying, and kneading methods.
- Characterization using 1H NMR, ROESY, FT-IR, DSC, SEM, and XRD.
- Hydrogel synthesis (pectin and pullulan) optimized using Response Surface Methodology.
- In vitro drug release studies at different pH values (2, 7, 7.4) at 37°C.
Main Results:
- Successful formation of phenothiazine-beta-cyclodextrin inclusion complexes confirmed by analytical techniques.
- Freeze-drying (FD) and microwave (MW) methods yielded the most suitable ICs for sustained release.
- Drug release kinetics best fitted the Riteger-Peppas and Peppas-Sahlin models.
Conclusions:
- The freeze-drying and microwave methods are superior for preparing phenothiazine-beta-cyclodextrin inclusion complexes.
- Optimized inclusion complexes facilitate sustained drug release.
- This research offers improved strategies for formulating challenging drugs.
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