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Effects Of Opioid-sparing General Anesthesia On Postoperative Nausea And Vomiting In Laparoscopic Gynecological Surgery.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Effects Of Opioid-sparing General Anesthesia On Postoperative Nausea And Vomiting In Laparoscopic Gynecological Surgery.

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Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery.

Sun Woo Nam¹, Sang-Hwan Do^2,3, Jung-Won Hwang^2,3

¹Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Korean Journal of Anesthesiology

|August 25, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Opioid-sparing anesthesia (OSA) significantly reduced postoperative nausea and pain in patients undergoing laparoscopic gynecological surgery. This approach also decreased the need for rescue analgesics without causing hemodynamic instability.

Keywords:

Analgesia Anesthesia Gynecologic surgical procedures Opioid

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Area of Science:

Anesthesiology
Surgical Outcomes
Pain Management

Background:

Postoperative nausea and vomiting (PONV) and pain are common after laparoscopic gynecological surgery.
Opioid-sparing anesthesia (OSA) is a strategy to minimize opioid use during and after surgery.
The efficacy of OSA in reducing PONV in this specific patient population requires further investigation.

Purpose of the Study:

To determine if opioid-sparing anesthesia (OSA) is effective in reducing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecological surgery.
To compare the incidence of PONV, pain scores, and analgesic requirements between OSA and traditional opioid-using anesthesia (OUA) groups.

Main Methods:

Adult patients undergoing elective laparoscopic gynecological surgery were randomized into two groups: OSA and OUA.

Opioid analgesics

Postoperative nausea and vomiting

Postoperative pain.

The OUA group received remifentanil during general anesthesia, while the OSA group received only a single dose of alfentanil for intubation.

Both groups received multimodal intravenous non-opioid analgesics postoperatively. PONV was assessed up to postoperative day 1.

Main Results:

The incidence of nausea in the post-anesthesia care unit (PACU) was significantly lower in the OSA group (31.7%) compared to the OUA group (51.7%) (P = 0.026).
Pain scores and the need for opioid analgesics were significantly reduced in the OSA group, with fewer patients requiring rescue analgesics (3.3% vs. 18.3%, P = 0.008).
No significant differences were observed in intraoperative vital signs, hemodynamic interventions, or length of PACU and hospital stay between the groups.

Conclusions:

Opioid-sparing anesthesia (OSA) effectively reduces postoperative nausea and pain in patients undergoing laparoscopic gynecological surgery.
OSA leads to a decreased requirement for rescue analgesics in the PACU.
The OSA approach does not compromise hemodynamic stability or prolong recovery time.