Consensus on glycemic management for patients with coronary heart disease and type 2 diabetes
Insights
Patients with coronary heart disease and type 2 diabetes face high cardiovascular risks. This consensus standardizes glycemic management using novel glucose-lowering medications like GLP-1 RAs and SGLT-2i to reduce these risks.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- High prevalence of coronary heart disease (CHD) and diabetes mellitus leads to significant residual cardiovascular risks.
- Existing interventions do not fully mitigate cardiovascular risks in diabetic CHD patients.
- Cardiologists show gaps in knowledge regarding type 2 diabetes screening and underutilize glucose-lowering medications with proven cardiovascular benefits, such as GLP-1 RAs and SGLT-2i.
Purpose of the Study:
- To standardize glycemic management for patients with CHD, including those with acute coronary syndrome, chronic coronary syndrome, and undergoing percutaneous coronary intervention.
- To provide guidance on screening, diagnosis, and comprehensive cardiovascular risk management for type 2 diabetes in CHD patients.
- To promote the standardized clinical application of glucose-lowering medications with demonstrated cardiovascular benefits.
Main Methods:
- Development of a consensus based on domestic and international guidelines.
- Review of the latest evidence-based research on glycemic management and cardiovascular risk reduction.
- Establishment of principles and algorithms for glucose-lowering treatment in CHD patients.
Main Results:
- The consensus outlines key points for type 2 diabetes screening and diagnosis in CHD patients.
- It details comprehensive cardiovascular risk management strategies.
- It clarifies the use of glucose-lowering medications with cardiovascular benefits, including GLP-1 RAs and SGLT-2i.
Conclusions:
- Standardized glycemic management is crucial for reducing cardiovascular risks in patients with CHD and type 2 diabetes.
- Increased awareness and appropriate prescription of novel glucose-lowering agents are necessary.
- This consensus provides a framework for optimizing cardiovascular risk reduction in this patient population.
Abstract:
The prevalence of patients with coronary heart disease (CHD) and diabetes mellitus is notably high, posing significant residual cardiovascular risks even after routine interventions such as antihypertensive, lipid-lowering, and antithrombotic treatments. Recent studies have demonstrated that certain glucose-lowering medications confer cardiovascular benefits for patients with type 2 diabetes. However, a survey indicates that cardiologists may not be fully acquainted with the optimal screening timing, indicators, and diagnostic criteria for type 2 diabetes, and there is insufficient awareness and a low rate of prescription of novel glucose-lowering medications with proven cardiovascular efficacy, such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 inhibitors (SGLT-2i). In this context, based on domestic and international guidelines or consensus and the latest evidence-based evidence, this consensus aims to standardize the glycemic management for patients with acute coronary syndrome, chronic coronary syndrome, and perioperative management for percutaneous coronary intervention. It highlights the key points of screening and diagnosis of type 2 diabetes, and the comprehensive management of cardiovascular risk in patients with CHD. The consensus elaborates on the principles and algorithms of glycemic management for CHD patients, without involving acute complications of diabetes, clarifies the clinical practice of glucose-lowering medications with cardiovascular benefits, and promotes the standardized use of these medications in cardiovascular and other related specialty fields. Additionally, it addresses the glucose-lowering treatment to comprehensively reduce cardiovascular risks.
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