Related Experiment Video
Updated: Jun 15, 2025
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Clinical experience with adaptive MRI-guided pancreatic SBRT and the use of abdominal compression to reduce treatment
William S Ferris1, Benjamin George1, Kristin A Plichta1
1Department of Radiation Oncology, University of Iowa, Iowa, IA, United States.
Introduction:
This work presents a method to treat stereotactic body radiation therapy (SBRT) for pancreatic cancer on a magnetic resonance-guided linear accelerator (MR-linac) using daily adaptation, real-time motion monitoring, and abdominal compression.
Methods:
The motion management and treatment planning process involves a magnetic resonance imaging (MRI) simulation with cine and 3D images, a computed tomography (CT) simulation with a breath-hold CT and a 4DCT, pre-treatment verification and planning MRI, and intrafraction MRI cine images.
Results:
The results from 26 patients were included in this work. Our motion management process results in consistent motion analysis on the CT simulation, MRI simulation, and each treatment fraction. The liver dome was found to be an overestimate of tumor superior/inferior (SI) motion for most patients. Adding compression reduced SI liver dome motion by 6.2 mm on average. Clinical outcomes are similar to those observed in the literature.
Conclusions:
In this work, we demonstrate how pancreatic SBRT can be successfully treated on an MR-linac using abdominal compression. This allows for an increased duty cycle compared to gating and/or breath-hold techniques.
