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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Updated: Jun 15, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Immune Infiltration Correlates with Transcriptomic Subtypes in Primary ER+ Invasive Lobular Breast Cancer.

Fangyuan Chen, Sayali Onkar, Jian Zou

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    This summary is machine-generated.

    This study reveals two breast cancer subtypes and immune patterns in ER+/HER2- invasive lobular cancers. A proliferative subtype showed more immunosuppressive cells, while a TAM-Low signature predicted better outcomes.

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    Area of Science:

    • Oncology
    • Immunology
    • Genomics

    Background:

    • Understanding the tumor microenvironment is crucial for breast cancer research.
    • Invasive lobular breast cancer (ILC) subtypes and their immune interactions require further investigation.

    Purpose of the Study:

    • To identify transcriptomic subtypes and immune infiltration patterns in ER+/HER2- ILC.
    • To explore the relationship between these subtypes, immune cells, and patient outcomes.

    Main Methods:

    • RNA sequencing (RNA-seq) and multiplex immunohistochemistry were used.
    • Analysis included 21 cases of ER+/HER2- invasive lobular breast cancer.

    Main Results:

    • Two transcriptomic subtypes and five immune infiltration patterns were identified.
    • A proliferative subtype correlated with increased immunosuppressive regulatory T-cells and macrophages.
    • A TAM-Low signature was associated with reduced pro-inflammatory TAMs and improved patient outcomes.

    Conclusions:

    • Distinct transcriptomic and immune profiles exist within ER+/HER2- ILC.
    • Immune cell infiltration, particularly regulatory T-cells and TAMs, influences ILC behavior and patient prognosis.
    • The TAM-Low signature may serve as a predictive biomarker for improved outcomes in ER+ tumors.