Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ozone induced pulmonary injury and respiratory dysfunction: Evidence, underlying mechanism and target investigation.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Positively-charged glycopolymer@AgNPs nanocomposites with exceptionally narrow size distribution and boosted performance against fungi.

Pest management science·2026
Same author

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma Pathophysiology.

Research square·2026
Same author

Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026).

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

GPX1 Drives Cuproptosis-Ferroptosis Resistance in Cold Tumors.

Free radical biology & medicine·2026
Same author

VTA dopamine inputs activate accumbal D1 receptors to promote alcohol seeking.

iScience·2026

Related Experiment Video

Updated: Jun 15, 2025

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
06:19

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

10.6K

Miniaturized Head-Mount Doppler Optical Coherence Tomography Scope for Freely Moving Mouse.

Jingyi Wang1,2, Qiao Ye3,4, Lidek Chou1

  • 1Beckman Laser Institute, University of California Irvine, Irvine, California 92612, United States.

ACS Photonics
|August 26, 2024
PubMed
Summary

A new, lightweight head-mount optical coherence tomography (OCT) system enables high-resolution, noninvasive brain imaging in freely moving mice, preserving natural behavior for neuroscience research.

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.0K
Author Spotlight: Advancements in In Vivo and Ex Vivo Retinal Imaging for Improved Glaucoma Diagnosis and Treatment
07:02

Author Spotlight: Advancements in In Vivo and Ex Vivo Retinal Imaging for Improved Glaucoma Diagnosis and Treatment

Published on: June 30, 2023

1.5K

Related Experiment Videos

Last Updated: Jun 15, 2025

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
06:19

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

10.6K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.0K
Author Spotlight: Advancements in In Vivo and Ex Vivo Retinal Imaging for Improved Glaucoma Diagnosis and Treatment
07:02

Author Spotlight: Advancements in In Vivo and Ex Vivo Retinal Imaging for Improved Glaucoma Diagnosis and Treatment

Published on: June 30, 2023

1.5K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Noninvasive brain imaging in freely moving subjects is crucial for understanding neurological disorders.
  • Existing imaging techniques can be invasive or restrict natural behavior.
  • Advancements in optical coherence tomography (OCT) offer potential for high-resolution, depth-resolved imaging.

Purpose of the Study:

  • To develop and present a miniaturized, head-mount OCT system for high-resolution brain imaging in freely moving mice.
  • To enable noninvasive, real-time visualization of brain structures and functions.
  • To facilitate the study of brain mechanisms and neurological disorders without behavioral disruption.

Main Methods:

  • Development of a 1.5 g head-mount optical coherence tomography (OCT) system.
  • Integration of swept-source OCT laser operating at 200 kHz for high-speed imaging.
  • Inclusion of functional OCT extensions: angiography and Doppler imaging.
  • Features include a 4x4 mm field of view, 7.4 μm axial resolution, and focal adjustability.

Main Results:

  • The system successfully achieved high-resolution, depth-resolved brain imaging in freely moving mice.
  • Functional OCT capabilities (angiography, Doppler) were demonstrated.
  • The lightweight design (1.5 g) ensured minimal impact on natural mouse behavior.
  • Real-time imaging was facilitated by the 200 kHz laser and system design.

Conclusions:

  • The miniaturized head-mount OCT system is a powerful, noninvasive tool for neuroscience research.
  • It allows for in-vivo study of brain function and pathology in naturalistic conditions.
  • This technology advances the ability to investigate neurological disorders and brain mechanisms.