Anesthesia-free In-office Hysteroscopic Morcellation for Endometrial Polyps: A Prospective Study

Area of Science:

• Gynecology
• Minimally Invasive Surgery
• Reproductive Medicine

Background:

• Endometrial polyps are common gynecological issues requiring treatment.
• Traditional hysteroscopic procedures often necessitate anesthesia and a surgical setting.
• There is a need for less invasive, office-based treatment options.

Purpose of the Study:

• To assess the feasibility and quality of anesthesia-free hysteroscopic morcellation for endometrial polyps.
• To evaluate the efficacy and safety of this minimally invasive approach.

Main Methods:

• A prospective, single-center, open-label, single-arm clinical trial.
• Ninety-five patients underwent anesthesia-free hysteroscopic morcellation using the TruClear™ 5C system in an office setting.
• Primary endpoint: surgical success rate. Secondary endpoints: operating time, fluid deficit, adverse events, pain (VAS scores), and recurrence.

Main Results:

• 100% surgical success rate achieved in all 95 patients.
• Mean operating time was 7.3 minutes with a low adverse event rate (2.1%).
• Mean Visual Analog Scale (VAS) pain scores ranged from 2.4 to 3.1, indicating tolerable pain. Recurrence rate was 2.1% at 6 months.

Conclusions:

• Anesthesia-free in-office hysteroscopic morcellation is a safe and feasible procedure for endometrial polyps.
• The technique demonstrates high quality, tolerable pain, and a low recurrence rate.
• This less-invasive approach is poised for broader clinical implementation.