Exploring New Schiff Bases: Synthesis, Characterization, and Multifaceted Analysis for Biomedical Applications.

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Biochemistry

Background:

• Schiff bases are versatile compounds with potential therapeutic applications.
• Developing novel compounds for treating neurodegenerative and stress-related disorders is crucial.

Purpose of the Study:

• To synthesize and characterize novel Schiff bases.
• To evaluate their α-amylase inhibitory, anticancer, anti-Alzheimer's, and stress resistance properties.

Main Methods:

• Synthesis of Schiff bases via acid-catalyzed reaction.
• Physicochemical characterization using LC-MS, FTIR, SEM, NMR, XRD.
• Thermal analysis (TGA, DTA, DTG) for kinetic parameter determination.
• In vitro and in silico evaluation of α-amylase inhibition.
• MTT assay for cytotoxicity against A549 lung cancer cells.
• Screening in Caenorhabditis elegans for anti-Alzheimer's and stress resistance.

Main Results:

• Schiff bases were successfully synthesized and characterized.
• Schiff base-2 exhibited superior α-amylase inhibition compared to acarbose.
• Both Schiff bases demonstrated significant anticancer activity against A549 cells.
• Compounds showed efficacy in Caenorhabditis elegans models for anti-Alzheimer's and stress resistance.

Conclusions:

• The synthesized Schiff bases possess promising therapeutic potential.
• These compounds could serve as leads for developing new drugs for Alzheimer's, stress disorders, and cancer.
• Further research is warranted to explore their full therapeutic capabilities.