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Cracking the Code: A Case Report on Low-Renin Hypertension
Fawwad A Ansari1, Bilal Hamid2, Inemesit Akpan1
1Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Cureus
|August 26, 2024
Summary
Low-renin hypertension (LRH) is a spectrum of conditions causing high blood pressure with low renin. This case highlights effective treatment with spironolactone for resistant LRH.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Background:
- Low-renin hypertension (LRH) presents as hypertension with suppressed serum renin levels.
- LRH encompasses a range of conditions, including essential hypertension and secondary causes.
Observation:
- A 57-year-old female with resistant hypertension was evaluated for secondary causes.
- Diagnostic workup revealed low renin levels and normal aldosterone.
- The patient had been on multiple antihypertensive medications without adequate blood pressure control.
Findings:
- Spironolactone therapy was initiated for the patient.
- Rapid and effective blood pressure normalization was observed following spironolactone treatment.
- This suggests a favorable response to mineralocorticoid receptor antagonism in this LRH case.
Implications:
- LRH is an under-recognized cause of difficult-to-control hypertension.
- Early identification and specific treatment strategies can improve patient outcomes.
- Mineralocorticoid receptor blockers and ENaC blockers show promise in managing LRH.
Keywords:
low-renin hypertensionprimary hyperaldosteronismresistant hypertensionsecondary hypertensionspironolactoneMore Related Videos
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