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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

55
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Cardiovascular Medicine And Haematology
  9. Haematology
  11. Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, Systemic Immune Inflammation Index And Efficacy Of Remote Ischemic Conditioning In Acute Ischemic Stroke: A Post Hoc Exploratory Analysis Of The Ricamis Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Cardiovascular Medicine And Haematology
  9. Haematology
  11. Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, Systemic Immune Inflammation Index And Efficacy Of Remote Ischemic Conditioning In Acute Ischemic Stroke: A Post Hoc Exploratory Analysis Of The Ricamis Study.

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Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Systemic Immune Inflammation Index and Efficacy of Remote Ischemic Conditioning in Acute Ischemic Stroke: A Post Hoc Exploratory Analysis of the RICAMIS Study.

Qi Wang1,2, Wen-Na Li3, Wuxiyar Otkur4

  • 1Department of Neurology, General Hospital of Northern Theater Command, Shenyang, 110016, People's Republic of China.

Journal of Inflammation Research
|August 26, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
ischemic strokeneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratioremote ischemic conditioning

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Remote ischemic conditioning (RIC) improved outcomes in acute ischemic stroke patients irrespective of inflammation markers like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune inflammation index (SII). High inflammation status showed a numerically greater benefit from RIC.

Area of Science:

  • Neurology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Remote ischemic conditioning (RIC) is a potential therapeutic strategy for acute ischemic stroke.
  • Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune inflammation index (SII), are associated with stroke outcomes.
  • The impact of these inflammatory markers on RIC efficacy remains unclear.

Purpose of the Study:

  • To investigate the effect of NLR, PLR, and SII on the efficacy of remote ischemic conditioning (RIC) treatment in patients with acute moderate ischemic stroke.
  • To evaluate whether pre-treatment inflammatory status modifies the functional outcome of RIC.

Main Methods:

  • Post-hoc analysis of the RICAMIS trial involving 1679 patients.
systemic immune-inflammation index
  • Patients were stratified into high and low groups based on pre-randomization NLR, PLR, and SII values.
  • The primary endpoint was poor functional outcome (modified Rankin Scale score 2-6) at 90 days, comparing RIC versus control subgroups and evaluating treatment-by-biomarker interactions.

    • Main Results:

    • RIC significantly improved functional outcomes compared to the control group, irrespective of inflammation status (NLR, PLR, SII).
    • A numerically greater improvement in outcomes was observed with RIC in patients with high inflammation markers (NLR, PLR, SII).
    • No significant interaction effect was found between RIC treatment and inflammation markers on clinical outcomes. NLR and SII were independently associated with functional outcomes.

    Conclusions:

    • Inflammation status does not appear to affect the overall efficacy of RIC in acute moderate ischemic stroke.
    • Patients with high inflammatory markers may experience a numerically greater benefit from RIC.
    • NLR and SII are independent predictors of functional outcomes in ischemic stroke patients, regardless of RIC treatment.