Long non‑coding RNAs as diagnostic and prognostic biomarkers for colorectal cancer (Review)
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View abstract on PubMed
Summary
This summary is machine-generated.Long non-coding RNAs (lncRNAs) in blood show promise as early diagnostic and prognostic biomarkers for colorectal cancer (CRC). Their altered expression levels offer a minimally invasive approach for detecting this widespread disease.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Colorectal cancer (CRC) is a leading cause of cancer death globally, often diagnosed late due to limited early symptoms and diagnostics.
- Current diagnostic methods for CRC face limitations, leading to late-stage detection in most patients.
- Long non-coding RNAs (lncRNAs) are emerging as critical players in CRC development and progression.
Purpose Of The Study
- To review the efficacy of circulating long non-coding RNAs (lncRNAs) in peripheral blood as diagnostic markers for colorectal cancer (CRC).
- To summarize the clinical significance of lncRNAs as prognostic markers for CRC.
- To explore the potential of lncRNAs in peripheral blood for minimally invasive CRC detection via liquid biopsy.
Main Methods
- Systematic literature review of studies analyzing altered expression levels of long non-coding RNAs (lncRNAs) in peripheral blood of colorectal cancer (CRC) patients.
- Evaluation of the diagnostic accuracy and clinical utility of identified lncRNAs.
- Synthesis of data on the prognostic value of circulating lncRNAs in CRC.
Main Results
- Circulating long non-coding RNAs (lncRNAs) demonstrate significant alterations in expression levels in colorectal cancer (CRC) patients compared to healthy individuals.
- Specific lncRNAs in peripheral blood show potential as sensitive and specific biomarkers for early CRC detection.
- Altered expression of certain lncRNAs correlates with clinical outcomes, indicating their prognostic value in CRC.
Conclusions
- Circulating long non-coding RNAs (lncRNAs) represent promising, minimally invasive biomarkers for both the diagnosis and prognosis of colorectal cancer (CRC).
- Further validation of lncRNAs in larger cohorts is warranted to establish their clinical application in liquid biopsy-based CRC testing.
- The study highlights the potential of lncRNAs to improve early detection and management strategies for colorectal cancer.
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