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IgA inhibitor to factor VIII/von Willebrand factor
British Journal of Haematology
|January 1, 1985
Summary
An acquired IgA inhibitor affected factor VIII/von Willebrand factor (VIII/vWf) and normal platelet function. This rare inhibitor impacted hemorrhagic diathesis beyond factor VIII coagulant (VIII:C) activity.
Area of Science:
- Hematology
- Immunology
Background:
- Acquired factor VIII inhibitors are rare but can cause severe bleeding.
- Immunoglobulin A (IgA) inhibitors are even rarer, with limited understanding of their mechanisms.