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Protective Effect of Memantine on Cisplatin-Induced Ototoxicity: An In Vitro Study
Soo Jeong Choi1, Soo Jin Lee1, Dabin Lee1
1Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.
Summary
Memantine protects auditory cells from cisplatin-induced ototoxicity by reducing apoptosis and oxidative stress. This suggests memantine may prevent hearing loss in cancer patients receiving chemotherapy.
Area of Science:
- Neuroscience
- Ototoxicity Research
- Pharmacology
Background:
- Cisplatin is a vital chemotherapy agent but causes ototoxicity, limiting its use.
- Developing strategies to mitigate cisplatin-induced hearing loss is crucial.
Purpose of the Study:
- To investigate the protective effects of memantine against cisplatin-induced ototoxicity.
- To evaluate memantine's potential to prevent chemotherapy-related hearing damage.
Main Methods:
- Utilized House Ear Institute Organ of Corti 1 (HEI-OC1) cells and cochlear explants.
- Assessed cell viability, apoptosis, reactive oxygen species (ROS), and Bcl-2/caspase-3 activity.
Main Results:
- Memantine significantly enhanced cell viability in auditory cells exposed to cisplatin.
- Reduced cisplatin-induced apoptosis and increased Bcl-2/caspase-3 activity, indicating anti-apoptotic and antioxidative effects.
Conclusions:
- Memantine demonstrates in vitro protective effects against cisplatin-induced ototoxicity.
- Memantine presents a potential therapeutic strategy for preventing hearing loss in patients undergoing cisplatin chemotherapy.
