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Are low cholesterol values associated with excess mortality?

C E Salmond, R Beaglehole, I A Prior

    British Medical Journal (Clinical Research Ed.)
    |February 9, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Higher cholesterol levels were linked to lower mortality rates from cancer and other causes in both men and women. This inverse relationship, particularly in women, persisted even after excluding early deaths, suggesting it wasn't due to pre-existing illness.

    Area of Science:

    • Epidemiology
    • Public Health
    • Biostatistics

    Background:

    • Cholesterol's role in cardiovascular disease is well-established.
    • The relationship between cholesterol and overall mortality, especially in specific populations, requires further investigation.
    • Previous studies have yielded conflicting results regarding cholesterol and mortality risk.

    Purpose of the Study:

    • To prospectively examine the association between serum cholesterol concentration and mortality over 17 years.
    • To investigate the relationship between cholesterol and specific causes of death (cancer, cardiovascular disease, other) in a New Zealand Maori population.
    • To determine if the observed associations were influenced by undetected illnesses.

    Main Methods:

    • Prospective cohort study involving 630 New Zealand Maori individuals aged 25-74.

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  • Mortality status determined in 1981 after a 17-year follow-up period.
  • Analysis using univariate, linear, and non-linear multivariate methods for survivorship data.

    • Main Results:

    • Significant inverse relationships were observed between serum cholesterol and total mortality in women.
    • Cholesterol showed a significant inverse association with cancer mortality in both men and women.
    • An inverse relationship was found for other causes of mortality in both sexes.

    Conclusions:

    • Serum cholesterol concentration is inversely associated with cancer mortality and other causes of death in this population.
    • The inverse association with total mortality in women remained significant after excluding early deaths, suggesting a genuine biological link.
    • These findings challenge traditional views and highlight the complex relationship between cholesterol and mortality across different causes and genders.