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Epidemiological characteristics of platelet aggregability.
British Medical Journal (Clinical Research Ed.)
|February 9, 1985
Summary
Platelet aggregability varies by age, sex, ethnicity, and lifestyle factors like smoking and alcohol consumption. Plasma fibrinogen concentration strongly influences platelet behavior, suggesting broader approaches to thrombosis prevention.
Area of Science:
- Cardiovascular Epidemiology
- Hematology
- Public Health
Background:
- Platelet aggregability is a key factor in thrombosis.
- Understanding its epidemiological characteristics is crucial for cardiovascular disease prevention.
Purpose of the Study:
- To establish the epidemiological characteristics of platelet aggregability.
- To identify factors influencing platelet aggregation in a general population.
Main Methods:
- Analysis of platelet aggregability in 958 participants from the Northwick Park Heart Study.
- Measurement of adenosine diphosphate-induced platelet aggregation velocity.
Main Results:
- Platelet aggregability increases with age and is higher in women, white individuals, and non-smokers.
- Alcohol consumption was inversely associated with aggregability.
- No significant association was found with obesity, oral contraceptive use, menopausal status, or lipid levels.
- Plasma fibrinogen concentration showed a strong positive association with platelet aggregability.
Conclusions:
- Platelet aggregability is influenced by multiple demographic and lifestyle factors.
- Plasma fibrinogen concentration is a significant determinant of platelet behavior.
- Modifying external factors like plasma fibrinogen may be as important as using antiplatelet agents for thrombosis prevention.