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Inner Retinal Microvasculature With Refraction in Juvenile Rhesus Monkeys.

Barsha Lal¹, Zhihui She¹, Krista M Beach¹

¹University of Houston College of Optometry, Houston, TX, USA.

Translational Vision Science & Technology

|August 26, 2024

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Inner retinal microvasculature changes in juvenile rhesus monkeys are linked to axial length and refractive error. These alterations may serve as early indicators for myopia development.

Area of Science:

Ophthalmology
Retinal Imaging
Vascular Biology

Background:

Refractive errors, such as myopia, are a growing global health concern.
Understanding the microvascular changes associated with refractive error development is crucial for early detection and intervention.

Purpose of the Study:

To characterize the inner retinal microvasculature in rhesus monkeys across a spectrum of refractive errors.
To investigate the relationship between refractive error parameters and microvascular metrics using optical coherence tomography angiography.

Main Methods:

Induction of refractive error in rhesus monkeys, followed by measurement of axial length and spherical equivalent refraction (SER).
Acquisition of optical coherence tomography angiography scans to analyze foveal avascular zone area, perfusion density, fractal dimension, and lacunarity of superficial and deep vascular complexes.

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Statistical analysis using Pearson correlations to determine relationships between variables.

Main Results:

Significant correlations were found between foveal avascular zone area, superficial vascular complex (SVC) perfusion density, and retinal thickness.
SVC perfusion density in the outer annulus decreased with increasing axial length.
Fractal dimensions of SVC and deep vascular complex (DVC), and DVC lacunarity showed significant correlations with axial length and SER.

Conclusions:

Inner retinal microvasculature parameters are associated with increasing axial length and SER in juvenile rhesus monkeys.
Alterations in retinal microvasculature may serve as potential biomarkers for refractive error development.
Findings suggest implications for understanding myopia-related changes in humans.