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Human Infection With IsrRAPXV: A Novel Zoonotic Bat-Derived Poxvirus.
Yael Paran1,2, Dan David3, Nir Rudoler3
1Infectious Diseases Unit, Tel Aviv Sourasky Medical Center.
The Journal of Infectious Diseases
|August 26, 2024
Summary
A novel poxvirus, IsrRAPXV, found in Egyptian fruit bats has been identified in a human patient. This discovery highlights the zoonotic potential of bat viruses and the need for protective measures.
Area of Science:
- Virology
- Zoonotic Diseases
- Public Health
Background:
- Bats are natural reservoirs for zoonotic viruses with global public health implications.
- A novel poxvirus, IsrRAPXV, was previously identified in Egyptian fruit bats, causing significant bat morbidity and mortality.
Purpose of the Study:
- To identify and characterize a poxvirus detected in a human patient presenting with systemic symptoms and severe hand lesions.
- To determine the etiological agent responsible for the patient's illness and its relationship to known bat viruses.
Main Methods:
- Quantitative polymerase chain reaction (qPCR) for viral detection.
- Whole genome sequencing for viral characterization.
- Phylogenetic analysis to establish viral relatedness.
Main Results:
- A poxvirus was identified in skin lesions of a female patient who volunteered at a bat shelter.
- The identified virus was confirmed as IsrRAPXV through qPCR and phylogenetic analysis, showing identity to the bat-derived strain.
- The patient had direct contact with sick and injured bats prior to symptom onset.
Conclusions:
- IsrRAPXV is confirmed as a zoonotic virus, capable of transmission from bats to humans.
- Veterinarians and bat shelter volunteers must adhere to strict safety protocols and use personal protective equipment (PPE) when handling bats.
