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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Association between magnesium depletion score and stroke in US adults with chronic kidney disease: A population-based
Chunqian Feng1, Chunling Peng2, Chengfu Li3
1Department of Internal Medicine, The Fifth People's Hospital of Longgang District, Shenzhen, Guangdong, China.
Insights
Magnesium depletion significantly increases stroke risk in chronic kidney disease (CKD) patients. Higher Magnesium Depletion Scores (MDS) indicate greater risk, independent of other factors.
Area of Science:
- Nephrology
- Neurology
- Nutritional Science
Background:
- Magnesium metabolism disorders are common in chronic kidney disease (CKD) patients.
- Magnesium is crucial for vascular integrity.
- The Magnesium Depletion Score (MDS) is a new metric for magnesium deficiency.
Purpose of the Study:
- To investigate the association between the Magnesium Depletion Score (MDS) and stroke risk in CKD patients.
- To explore the relationship between magnesium deficiency and stroke outcomes in this population.
Main Methods:
- Cross-sectional, population-based study using National Health and Nutrition Examination Survey data (2009-2016).
- Analyzed 3536 CKD patients.
- Used sample-weighted multivariate logistic regression to assess stroke risk and MDS.
Main Results:
- Stroke prevalence was 8.6% in the studied CKD population.
- Lower dietary magnesium intake and higher MDS scores were linked to increased stroke risk.
- A dose-dependent relationship was observed between MDS scores and stroke likelihood, independent of other factors.
Conclusions:
- Magnesium depletion is an independent risk factor for stroke in CKD patients.
- Higher MDS scores are associated with a heightened risk of stroke.
Background:
Magnesium ion metabolism disorder is pervasive in the chronic kidney disease population, which is affected by many factors. Magnesium ion plays an important role in maintaining vascular functional integrity.. The Magnesium Depletion Score (MDS), serving as a novel metric for the assessment of magnesium deficiency, has not been thoroughly investigated for its association with stroke in patients with chronic kidney disease (CKD). Therefore, this study aims to explore the relationship between the MDS index and stroke in CKD patients.
Methods:
We conducted a cross-sectional population-based study using data from the National Health and Nutrition Examination Survey 2009-2016 to explore the impact of MDS on the stroke outcome of CKD patients. The primary outcome was the risk of stroke in CKD patients. Sample-weighted multivariate logistic regression was used in our analysis.
Results:
In this study of 3536 CKD patients from the database, we found an 8.6 % prevalence of stroke with higher stroke risk in older individuals and males. Lower dietary magnesium intake and higher MDS scores were significantly associated with stroke risk. Multivariate logistic regression analysis revealed a dose-dependent relationship between MDS scores and stroke likelihood, independent of demographic and clinical factors. Subgroup analysis confirmed these findings, particularly in those with hypertension, diabetes, and obesity, without significant interactions (all p > 0.05).
Conclusion:
Magnesium depletion is independently associated with a heightened stroke risk in chronic kidney disease patients.
