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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...

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Related Experiment Video

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Acupuncture for obesity：study protocol for a randomised controlled trial.

Xinyu Zhao1, Yang Wang2,3, Xiaoyi Li1

  • 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

BMJ Open
|August 26, 2024
PubMed
Summary

This randomized trial investigates acupuncture for obesity treatment. It compares verum acupuncture to sham acupuncture in 160 participants over 12 weeks to assess weight loss and safety.

Keywords:
COMPLEMENTARY MEDICINEClinical TrialObesity

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Area of Science:

  • Integrative and Complementary Medicine
  • Obesity Research
  • Clinical Trials

Background:

  • Obesity presents a significant global public health challenge.
  • Acupuncture is a common clinical intervention for obesity, but evidence of its efficacy is limited.
  • There is a need for rigorous trials to establish acupuncture's effectiveness for weight management.

Purpose of the Study:

  • To evaluate the efficacy and safety of acupuncture for treating obesity.
  • To compare verum acupuncture with sham acupuncture in a randomized controlled trial.
  • To provide robust evidence regarding acupuncture's role in obesity management.

Main Methods:

  • A parallel, randomized, sham-controlled trial involving 160 eligible participants with obesity.
  • Participants assigned 1:1 to verum or sham acupuncture groups, treated three times weekly for 12 weeks, with a 16-week follow-up.
  • Primary outcome: percentage change in body weight at Week 12. Secondary outcomes include BMI, waist circumference, body fat percentage, and various health-related quality of life measures.

Main Results:

  • Primary outcome data (percentage change in body weight at Week 12) will be analyzed.
  • Secondary outcomes including anthropometric measures, metabolic markers, and quality of life indicators will be assessed.
  • Safety data, including adverse events, will be meticulously recorded throughout the trial.

Conclusions:

  • The study aims to determine if acupuncture is an effective and safe treatment for obesity.
  • Findings will contribute to evidence-based clinical practice guidelines for obesity management.
  • Results will inform patients and healthcare providers about the potential benefits of acupuncture for weight loss.