Magnolol's Therapeutic Efficacy and Immunomodulatory Effects in Oral Squamous Cell Carcinoma

Chien-Fu Tseng ^1,2, Hsin-Ming Chen ^1,3,4,5, Tsai-Lan Liao ^6,7

¹Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan, R.O.C.
²Department of Dentistry, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
³Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan, R.O.C.
⁴Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan, R.O.C.
⁵Department of Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.
⁶Department of Biomedical Imaging and Radiological Science, National Yang-Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
⁷Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
⁸Department of Molecular Biology and Cell Research, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.; joe.0221@gmail.com.
⁹Department of Psychiatry, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.; wt820368@yahoo.com.tw.
¹⁰Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan, R.O.C.
¹¹Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan, R.O.C.; shkok@ntu.edu.tw.

⁰Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan, R.O.C.

In Vivo +

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August 26, 2024

View abstract on PubMed

Summary

Magnolol significantly reduced oral squamous cell carcinoma (OSCC) tumor growth and induced apoptosis in vivo. This natural compound also enhanced anti-tumor immune cells without causing toxicity, showing therapeutic potential for OSCC.

Area Of Science

Oncology
Pharmacology
Immunology

Background

Oral squamous cell carcinoma (OSCC) is a significant health concern.
Magnolol, a natural compound, shows promise for anticancer applications.
Investigating magnolol's efficacy and mechanisms in OSCC is crucial.

Purpose Of The Study

To evaluate magnolol's effectiveness in inhibiting OSCC progression.
To explore the mechanisms behind magnolol's action in OSCC.
To assess magnolol's impact on tumor pathology, toxicity, and immunomodulation.

Main Methods

Utilized a MOC1-bearing orthotopic model to assess magnolol's effect on tumor progression.
Employed hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and biochemical analysis for pathology and toxicity assessment.
Conducted flow cytometry to investigate magnolol's immunoregulatory effects.

Main Results

High-dose magnolol significantly reduced tumor volume (by 70%) and weight loss in vivo.
Magnolol induced caspase-dependent apoptosis, increasing caspase-3, -8, and -9 expression.
No significant toxicity was observed; magnolol enhanced natural killer cells, dendritic cells, and cytotoxic T cells while reducing suppressor cells.

Conclusions

Magnolol exhibits significant antitumor efficacy against OSCC.
Magnolol possesses immunomodulatory benefits, enhancing anti-tumor immunity.
Magnolol shows potential as a therapeutic agent for oral squamous cell carcinoma.

Keywords:

CD8 T cells Magnolol apoptosis immunosuppressive oral squamous cell carcinoma

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