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Hepatic sequestration in sickle cell anaemia.

C S Hatton, C Bunch, D J Weatherall

    British Medical Journal (Clinical Research Ed.)
    |March 9, 1985
    PubMed
    Summary
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    Sickle cell anemia patients can experience liver enlargement and low hemoglobin during crises. This liver complication, caused by sickled red blood cells, requires monitoring during sickle cell crises.

    Area of Science:

    • Hematology
    • Hepatology
    • Internal Medicine

    Background:

    • Sickle cell anemia is a genetic blood disorder characterized by abnormal hemoglobin.
    • Vaso-occlusive crises are common complications, leading to pain and organ damage.

    Observation:

    • Two patients with sickle cell anemia presented with acute hepatic enlargement.
    • A significant drop in hemoglobin concentration was noted concurrently with liver enlargement.

    Findings:

    • No significant liver function abnormalities or signs of heart failure were observed.
    • The primary cause is hypothesized to be the sequestration of sickled erythrocytes within the liver.

    Implications:

    • This hepatic complication may be analogous to splenic sequestration and the sickle lung syndrome.

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  • Regular liver size monitoring is crucial in sickle cell crisis management to prevent overlooking this condition.