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Related Concept Videos

Hazard Ratio01:12

Hazard Ratio

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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
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  11. Nonlinear Association Between Non-high-density Lipoprotein Cholesterol To High-density Lipoprotein Cholesterol Ratio And Hyperuricemia In Cancer Patients: Evidence From Nhanes 2007-2018

Nonlinear association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hyperuricemia in cancer patients: evidence from NHANES 2007-2018

Ran He1, Qilei Zhu2, Youjun Ye2

  • 1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Lipids in Health and Disease
|August 26, 2024

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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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View abstract on PubMed

Summary
This summary is machine-generated.

Cancer patients with higher non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) have increased odds of hyperuricemia (HUA). This non-linear association was significant, especially in males and those without a stroke history.

Area of Science:

  • Cardiovascular Health
  • Metabolic Disorders
  • Oncology

Background:

  • Cancer patients exhibit higher hyperuricemia (HUA) rates than the general population.
  • Lipid metabolism is implicated, but the NHHR-HUA relationship in cancer patients remains unclear.

Purpose of the Study:

  • To investigate the non-linear association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hyperuricemia (HUA) in cancer patients.

Main Methods:

  • Utilized NHANES database (2007-2018) with 2826 participants.
  • Employed multivariable logistic regression, restricted cubic splines (RCS), and subgroup analyses.
  • Examined associations with HUA and gout, exploring subgroup differences.

Main Results:

Keywords:
CancerCross-sectional studyHyperuricemiaNHANES

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  • A 24.30% HUA prevalence was observed.
  • Increased NHHR correlated with higher HUA odds (16% per unit increase).
  • Highest NHHR tertile showed 1.84x higher HUA odds; no significant gout association. RCS confirmed non-linear positive association, stronger in males and non-stroke patients.

Conclusions:

  • A significant non-linear association exists between NHHR and HUA in cancer patients.
  • The NHHR-HUA link is particularly notable in males and patients without stroke history.
NHHR