Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

2.3K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.3K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Antimicrobial Proteins01:23

Antimicrobial Proteins

951
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
951
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

765
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
765
Humoral Immune Responses01:36

Humoral Immune Responses

72.3K
Overview
72.3K
Antibody Actions01:26

Antibody Actions

1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyphosphates Attenuate Interleukin-12 Production in Macrophages Infected With Legionella pneumophila.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Proton-Activated Chloride Channel 1 (PACC1) is essential for innate host defense against bacterial sepsis.

bioRxiv : the preprint server for biology·2026
Same author

Reply to Chong et al.: Investigating TGFβ1 biological activities using genetically engineered mouse strains.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation.

European heart journal open·2024
Same author

Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling.

Blood·2023

Related Experiment Video

Updated: Jun 15, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.6K

The complement system: A key player in the host response to infections.

Archana Jayaraman1, Sarah Walachowski1,2, Markus Bosmann1,2

  • 1Department of Medicine, Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.

European Journal of Immunology
|August 27, 2024
PubMed
Summary

Host-pathogen interactions are crucial for understanding infections and antimicrobial resistance. This review explores how pathogens and complement system deficiencies impact host defense, and discusses new therapeutic strategies.

Keywords:
Complement deficiencyComplement hyperactivationImmune defensePneumoniaSepsis

More Related Videos

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

8.8K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

5.8K

Related Experiment Videos

Last Updated: Jun 15, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.6K
Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

8.8K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

5.8K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Microbiology

Background:

  • Infections pose a significant global health and economic challenge, exacerbated by antimicrobial resistance.
  • The complement system is vital for host defense against pathogens, bridging innate and adaptive immunity.
  • Pathogens have evolved mechanisms to evade complement-mediated killing, and complement deficiencies increase infection susceptibility.

Purpose of the Study:

  • To review critical aspects of complement-pathogen interactions during infection.
  • To discuss strategies for designing therapies to mitigate complement dysfunction and limit tissue injury.

Main Methods:

  • This is a review article, synthesizing existing knowledge on complement-pathogen interactions.

Main Results:

  • Pathogens can evade complement by co-opting host regulators.
  • Complement deficiencies impair pathogen eradication, increasing infection risk.
  • Overwhelming infections can cause harmful, uncontrolled complement activation and inflammation.

Conclusions:

  • Understanding complement-pathogen interactions is essential for developing effective treatments.
  • Therapeutic strategies targeting complement dysfunction are needed to manage infections and prevent tissue damage.