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Related Experiment Video

Updated: Jun 15, 2025

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

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Nellix Device Failure Mechanisms Analysis on Explanted Grafts.

Léna Christ1, Salomé Kuntz1,2, Damir Vakhitov1,3

  • 1GEPROMED, Strasbourg, France.

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
|August 27, 2024
PubMed
Summary

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Degradation of the polymer in Nellix endovascular aneurysm sealing devices can cause device failure, leading to endoleaks and migration. Patients require lifelong surveillance due to unpredictable device performance.

Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Vascular Surgery

Background:

  • The Nellix device, used for endovascular aneurysm sealing (EVAS), has shown poor durability.
  • Understanding the material degradation of EVAS devices is crucial for patient safety.

Purpose of the Study:

  • To investigate the reasons for the poor durability of the Nellix EVAS device.
  • To examine the structural integrity of the device's polymer endobags and metal stents.

Main Methods:

  • Analysis of 21 explanted Nellix endoprostheses.
  • Visual examination of stent structures and instrumental examination of polymer endobags.
  • In vitro testing of polymer samples under simulated implantation conditions (wet and dry exposure).
Keywords:
aortic aneurysmdegradationendoleaksendoprosthesisvascular prostheses

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Related Experiment Videos

Last Updated: Jun 15, 2025

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

6.7K
Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
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Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Published on: January 15, 2017

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Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor
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Main Results:

  • Iatrogenic defects were found in 76% of metal stents and 95% of endobags.
  • Polymer disintegration due to degradation occurred in 71% of cases.
  • Degraded polymer lost significant weight and volume upon dehydration, with partial recovery in saline.

Conclusions:

  • Polymer degradation, evidenced by weight and volume loss during dehydration, is a likely cause of Nellix device failure.
  • This degradation can lead to endoleaks and device migration.
  • Patients with Nellix endografts require enhanced, lifelong surveillance due to unpredictable performance and potential for device failure.