Dihydroquercetin-Loaded Liposomes Change Fibrous Tissue Distribution in the Bleomycin-Induced Fibrosis Model.
E V Ivanov1, M R Akhmetshina1, A R Gizatulina1
1Faculty of Medicine, Lomonosov Moscow State University, Moscow, 119991 Russian Federation.
Acta Naturae
|August 27, 2024
Summary
Dihydroquercetin (DHQ) delivered via liposomes altered fibrosis progression in a rat model of pulmonary fibrosis. This antioxidant treatment shifted fibrous tissue, potentially improving lung function by reducing interstitial fibrosis.
Area of Science:
- Biomedical Science
- Pharmacology
- Respiratory Medicine
Background:
- Pulmonary fibrosis is a progressive lung disease with limited treatment options.
- Oxidative stress plays a role in the pathogenesis of pulmonary fibrosis.
- Dihydroquercetin (DHQ) is a natural antioxidant with potential antifibrotic properties.
Purpose of the Study:
- To investigate the therapeutic effects of liposome-encapsulated dihydroquercetin (DHQ) on bleomycin-induced pulmonary fibrosis in rats.
- To assess the impact of DHQ on lung function, lesion volume, and fibrous tissue distribution.
Main Methods:
- Pulmonary fibrosis was induced in rats using intratracheal bleomycin.
- Rats received liposomal DHQ or saline for 7 days.
- Lung function and lesion volume were evaluated using 7T 1H MRI at 30 days.
- Histological examination with Masson's trichrome staining quantified fibrous tissue.
Main Results:
- Liposomal DHQ treatment significantly altered fibrous tissue distribution within lung lesions.
- Increased fibrous tissue was observed in the center of lesions, with decreased interstitial fibrosis.
- Treated lungs showed lower density, suggesting a potential functional improvement.
Conclusions:
- Dihydroquercetin encapsulated in liposomes modulates the progression of bleomycin-induced pulmonary fibrosis.
- Altering fibrosis distribution may restrict inflammation and improve lung function.
- Liposomal DHQ shows promise as a therapeutic strategy for pulmonary fibrosis.
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