Engineered photoresponsive biohybrids for tumor therapy

Area of Science:

• Biomaterials Science
• Nanotechnology
• Cancer Therapeutics

Background:

• Engineered biohybrids are emerging as innovative biomimetic platforms for cancer therapy.
• Photoresponsive biohybrids show significant potential against tumors due to their biomimetic properties and enhanced therapeutic functions.

Purpose of the Study:

• To summarize the design principles of engineered photoresponsive biohybrids.
• To review the latest advancements in their application for tumor therapy.

Main Methods:

• Highlighting representative engineered photoresponsive biohybrids (biomolecule-associated, cell membrane-based, eukaryotic cell-based, bacteria-based, algae-based).
• Presenting tumor therapeutic modalities including photothermal therapy, photodynamic therapy, synergistic therapy, and combination therapy with tissue regeneration.

Main Results:

• Engineered photoresponsive biohybrids demonstrate diverse designs and applications in cancer treatment.
• Various therapeutic strategies leverage these biohybrids for enhanced tumor targeting and destruction.

Conclusions:

• Photoresponsive biohybrids represent a promising frontier in cancer therapy.
• Challenges and future perspectives for clinical translation are discussed, highlighting the need for further research and development.