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Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy
Yuyu Li1,2,3, Jifang Wang1,4, Jun Xie1
1Department of Cardiology National Cardiovascular Disease Regional Center for Anhui the First Affiliated Hospital of Anhui Medical University Hefei China.
Abstract:
Atherosclerosis is a typical chronic inflammatory vascular disease that seriously endangers human health. At present, oral lipid-lowering or anti-inflammatory drugs are clinically used to inhibit the development of atherosclerosis. However, traditional oral drug treatments have problems such as low utilization, slow response, and serious side effects. Traditional nanodrug delivery systems are difficult to interactively recognize by normal biological organisms, and it is difficult to target the delivery of drugs to target lesions. Therefore, building a biomimetic nanodrug delivery system with targeted drug delivery based on the pathological characteristics of atherosclerosis is the key to achieving efficient and safe treatment of atherosclerosis. In this review, various nanodrug delivery systems that can target atherosclerosis are summarized and discussed. In addition, the future prospects and challenges of its clinical translation are also discussed.
Insights
Biomimetic nanodrug delivery systems offer targeted treatment for atherosclerosis, overcoming limitations of traditional therapies. These advanced systems promise improved efficacy and safety for managing this chronic inflammatory vascular disease.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Atherosclerosis is a chronic inflammatory vascular disease posing significant health risks.
- Current oral therapies for atherosclerosis exhibit limitations including poor drug utilization, slow response, and adverse side effects.
- Existing nanodrug systems lack specific targeting and interaction with biological organisms, hindering lesion delivery.
Purpose of the Study:
- To review and discuss nanodrug delivery systems designed for targeted atherosclerosis treatment.
- To highlight the importance of biomimetic nanodrug systems tailored to atherosclerotic pathological characteristics.
- To explore the clinical translation prospects and challenges of these advanced nanotechnologies.
Main Methods:
- Literature review of nanodrug delivery systems for atherosclerosis.
- Analysis of biomimetic strategies for targeted drug delivery.
- Discussion of pathological characteristics of atherosclerosis for system design.
Main Results:
- Various nanodrug delivery systems capable of targeting atherosclerosis have been identified and analyzed.
- Biomimetic approaches show potential for enhanced targeting and interaction with biological systems.
- The review synthesizes current advancements in nanomedicine for atherosclerosis treatment.
Conclusions:
- Biomimetic nanodrug delivery systems represent a promising strategy for efficient and safe atherosclerosis treatment.
- Targeted delivery based on atherosclerotic pathology is crucial for overcoming current therapeutic challenges.
- Further research and development are needed to facilitate the clinical translation of these nanotechnologies.
