Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.0K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.0K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.1K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.1K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

906
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
906
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

5.7K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
5.7K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.3K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Interplay between Osteoarthritis and the Microbiome-joint Axis: A Systemic Perspective on Novel Therapeutic Targets.

Current rheumatology reviews·2026
Same author

Retroperitoneal Myolipoma with Hip Invasion: A Case Report.

Reports (MDPI)·2026
Same author

Muscle and bone: not just neighbours, but interdependent teammates in wheelchair users.

European journal of applied physiology·2026
Same author

Salvage Reverse Shoulder Arthroplasty for Failed Proximal Humeral Fracture Fixation with Broken Implant.

Orthopedic reviews·2026
Same author

Ruptured Baker's Cyst Demystified: Current Evidence, Diagnostic Strategies, and Treatment Options for an Under-Recognized Condition.

Cureus·2026
Same author

Salvage Total Hip Arthroplasty After Cephalomedullary Nail Failure Due to Nonunion in a Pertrochanteric Fracture: A 10-Year Follow-Up.

Cureus·2026

Related Experiment Video

Updated: Jun 15, 2025

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.3K

Juvenile Osteochondritis Dissecans: Current Concepts.

Ibrahim Akkawi1, Hassan Zmerly2, Maurizio Draghetti1

  • 1Orthopedics, Casa di Cura Villa Erbosa, Bologna, ITA.

Cureus
|August 27, 2024
PubMed
Summary
This summary is machine-generated.

Juvenile osteochondritis dissecans (JOCD) of the knee affects young patients and involves subchondral bone and articular cartilage damage. MRI is crucial for diagnosing JOCD stability and guiding treatment, with surgery often successful for unstable or persistent cases.

Keywords:
autologous adipose-derived mesenchymal stem cell implantationautologous chondrocyte implantationautologous osteochondral transferdrillingjuvenile osteochondritis dissecansmicrofracture

More Related Videos

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.3K
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
07:06

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

4.4K

Related Experiment Videos

Last Updated: Jun 15, 2025

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.3K
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.3K
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
07:06

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Published on: July 6, 2022

4.4K

Area of Science:

  • Orthopedics
  • Pediatric Sports Medicine
  • Radiology

Background:

  • Juvenile osteochondritis dissecans (JOCD) affects the knee in skeletally immature patients.
  • It involves damage to subchondral bone and articular cartilage.
  • Etiology is debated, with theories including ischemia, trauma, and genetics.

Purpose of the Study:

  • To review the etiology, incidence, clinical presentation, imaging, classification, and treatment of JOCD of the knee.
  • To highlight the role of MRI in assessing JOCD stability.
  • To summarize treatment strategies for JOCD.

Main Methods:

  • A narrative review of 56 PubMed articles published up to March 16, 2024.
  • Keywords used: knee, juvenile, osteochondritis dissecans.
  • Focus on studies involving patients under 20 years of age.

Main Results:

  • Radiographs are insufficient for determining OCD lesion stability.
  • MRI is essential for assessing JOCD stability and informing treatment decisions.
  • Nonsurgical treatment is common for stable lesions; surgery offers good healing for unstable or refractory cases.

Conclusions:

  • JOCD requires careful evaluation, with MRI being key for stability assessment.
  • Treatment approaches vary from conservative management for stable lesions to surgical intervention for unstable or persistent JOCD.
  • Understanding JOCD's multifaceted nature is crucial for effective patient management.