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Related Experiment Video

Updated: Jun 15, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
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Developing organs-on-chips for biomedical applications.

Lingyu Sun1,2, Hanxu Chen1, Dongyu Xu1

  • 1Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing China.

Smart Medicine
|August 27, 2024
PubMed
Summary
This summary is machine-generated.

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Organs-on-chips offer advanced in vitro models that mimic human physiology, overcoming limitations of traditional methods. This review explores their applications in biology, chemistry, and medicine.

Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • In Vitro Models

Background:

  • Organs-on-chips are gaining interest as bionic in vitro models of human organs.
  • They overcome limitations of animal and 2D cell models, including species differences and poor predictability.
  • These chips can replicate complex physiological conditions like cell interactions and biofluid dynamics.

Purpose of the Study:

  • To review organs-on-chips for biomedical applications.
  • To introduce key elements and manufacturing techniques of organs-on-chips.
  • To highlight cutting-edge applications in biological analysis, drug development, and robotics.

Main Methods:

  • Review of existing literature on organs-on-chips.
  • Analysis of key components and fabrication processes.
Keywords:
biosensingcell culturedrug screeningmicrofluidicsorgans‐on‐chipstissue engineering

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  • Examination of current and emerging applications in biomedical fields.

    • Main Results:

    • Organs-on-chips provide superior in vitro models compared to traditional methods.
    • They enable the study of complex human physiological conditions.
    • Applications span biological analysis, drug development, and robotics.

    Conclusions:

    • Organs-on-chips are powerful tools for diverse biomedical applications.
    • Further development holds significant promise for future research and development.
    • The technology offers a path towards more predictive and reliable biomedical research.