Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Stem Cell Culture01:17

Stem Cell Culture

5.1K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.1K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.0K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.8K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

mRNA-laden LNP-enabled in situ CAR-macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing.

Research (Washington, D.C.)·2026
Same author

LAPTM5-dependent lipophagy enhances ferroptosis sensitivity in glioma cells.

Translational cancer research·2026
Same author

Micromotion friction microspheres massage cells to promote interfacial tissue fusion and regeneration.

Biomaterials·2026
Same author

Sprayable <i>Lactococcus lactis</i>-Nanocatalyst Gel for Postsurgical Immunomodulation in Preclinical Oral Squamous Cell Carcinoma.

Journal of the American Chemical Society·2026
Same author

Lipid-Polymer Hybrid Nanoparticles (LPHNPs) for RNA Delivery.

Accounts of chemical research·2026
Same journal

Flexible Porous Pomelo Pith Derived Janus Liquid Metal and Adhesive Hydrogel Hybrid Electronic Skins.

Smart medicine·2026
Same journal

Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.

Smart medicine·2026
Same journal

Advances in Hydrogel Tissue Engineering for Spinal Cord Injury Repair.

Smart medicine·2026
Same journal

Hydrogels for Bone Repair: Construction Strategies and Applications.

Smart medicine·2026
Same journal

Targeting Sphingosine-1-Phosphate Signaling Attenuates Doxorubicin-Aggravated Bone Loss in Obese Breast Cancer Mice.

Smart medicine·2026
Same journal

Constructing Neuroinflammation-On-A-Chip for Traditional Chinese Medicine Extracts Evaluation.

Smart medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2025

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

10.3K

Reprogramming stem cells in regenerative medicine.

Jiayi Mao1, Qimanguli Saiding2, Shutong Qian1

  • 1Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.

Smart Medicine
|August 27, 2024
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer a promising alternative to embryonic stem cells for regenerative medicine. Research explores iPSC reprogramming technologies and their applications in treating diseases like neurological disorders and spinal cord injuries.

Keywords:
cell therapiescellular reprogramminghuman disease modelinduced pluripotent stem cellstissue regeneration

More Related Videos

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

19.9K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.2K

Related Experiment Videos

Last Updated: Jun 15, 2025

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

10.3K
Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

19.9K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.2K

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Induced pluripotent stem cells (iPSCs) are generated from adult somatic cells via reprogramming.
  • iPSCs possess unlimited proliferation and differentiation potential, bypassing ethical concerns associated with embryonic stem cells (ESCs).
  • They hold significant promise for cell therapy, drug screening, and disease modeling.

Purpose of the Study:

  • To review diverse iPSC reprogramming technologies, including biotechnological, chemical, and physical methods.
  • To examine recent advancements in iPSC-based regenerative therapies for various clinical diseases.
  • To focus on translational clinical research and future potential of iPSCs in medicine.

Main Methods:

  • Review of reprogramming techniques (biotechnological, chemical, physical).
  • Analysis of current research on iPSC applications in disease treatment.
  • Evaluation of translational clinical research and future prospects.

Main Results:

  • Various reprogramming methods have distinct strengths and limitations.
  • iPSCs are actively used in studying hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries.
  • Significant progress has been made in iPSC-based regenerative therapies.

Conclusions:

  • iPSC technology offers broad applications in cell therapy, drug screening, and disease modeling.
  • Advancements in iPSC research are poised to drive breakthroughs in cellular therapy and tissue regeneration.
  • The future of iPSCs in regenerative medicine is promising, with ongoing research addressing potential challenges.