Histological Chorioamnionitis - Experience from a Tertiary Care Center.

Area of Science:

• Obstetrics and Gynecology
• Pathology
• Infectious Diseases

Background:

• Chorioamnionitis (CA) signifies intra-amniotic infection, detectable via fetal membrane histopathology.
• Understanding CA's histological features is crucial for clinical management and outcomes.

Purpose of the Study:

• To investigate the characteristics of all histological chorioamnionitis cases over a five-year period.
• To analyze the prevalence and patterns of inflammation in chorioamnionitis.

Main Methods:

• Retrospective cross-sectional study (2015-2019) of 78 women with confirmed chorioamnionitis.
• Data collected from hospital information system and analyzed using SPSS statistical methods.

Main Results:

• Average patient age was 36.18 years; 37.2% were stage 1, 32% stage 2, and 30.7% stage 3.
• Umbilical cord inflammation occurred in nearly half of cases; placental inflammation was less frequent.
• Bacterial infection was the primary cause, with Streptococcus agalactiae being the most prevalent strain.

Conclusions:

• The majority of histological chorioamnionitis cases were mild (stage 1).
• Umbilical cord and placental inflammation were common co-occurrences.
• Bacterial infections, especially Streptococcus agalactiae, were the leading cause of chorioamnionitis.