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Updated: Sep 28, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 24, 2013
Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin
Abstract:
Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.
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